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Women's Health
Female Sexual Dysfunction



Women's Health Overview


Female Sexual Dysfunction

Women's Health
Female Sexual Dysfunction
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Female Sexual Dysfunction (FSD) is often overlooked and under-treated. While treatments for men experiencing erectile dysfunction are readily available, many women are left wondering what options are available to them.

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Symptoms of Sexual Dysfunction

Patients with FSD exhibit a myriad of sexual symptoms. Research has shown that 43% of women suffer from one or more of these conditions and often present with physical and psychological attributes. 

  • Hypoactive Sexual Desire Disorder (HSDD) – Characterized by low sexual desire 
  • Sexual Arousal Disorder – Desire for sex might be intact, but the patient might have difficulty or be unable to become aroused or maintain arousal during sexual activity. 
  • Orgasmic Disorder – Persistent or recurrent difficulty in achieving orgasm after sufficient sexual arousal and ongoing stimulation. 
  • Sexual Pain Disorder – Pain associated with sexual stimulation or vaginal contact

Defy Medical offers several treatment options that have shown positive outcomes in women.


(Shifren JL, Obstet Gynecol.2008 Nov;112(5):970-8) 

What causes FSD?

Sex is not only an integral part of any relationship, studies have proven it is beneficial to your health. A healthy sex life decreases stress and heart disease, while increasing happiness and sense of well-being.

Women can experience sexual dysfunction at various stages of life. Many factors play a role in loss of enjoyment during sex. This decline can result from changes that are hormonal, physical, psychological, or relational.

More specifically, some of the contributors to low female libido include:

  • Decreased testosterone and estrogen levels 
  • Painful intercourse/dryness 
  • Medication side effects 
  • Chronic health conditions 
  • Loss of a spouse or partner 
  • Lack of emotional intimacy 
  • Conflict 
  • Stress 
  • Mood concerns 
  • Certain medical conditions 
  • Psychological or emotional issues

Sexual Performance in Women

Hormones, Aging and Sex

Aging results in a progressive decline in sex hormones such as estradiol and testosterone. Although women produce a much lower amount of testosterone than men, this decline is noticed throughout the whole body. Testosterone is responsible for a woman's sexual desire and responsiveness, mood, sense of well-being and mental acuity. As it does in men, testosterone plays a role in maintaining a woman’s desire.

Restoring optimal hormone balance can help improve your desire and reverse some of the symptoms associated with FSD. When restoring hormones is not enough, there are other treatment options available.

Available Treatments

Libido Cream is a topical cream applied to the clitoris or external genitalia to increase blood flow to the area and improve sensitivity and orgasm response.

Libido Cream is compounded by an FDA-registered pharmacy from a mixture of six prescription products that include: 

  • Aminophylline 
  • Ergoloid mesylate 
  • L-arginine 
  • Pentoxifylline 
  • Sildenafil citrate 
  • Testosterone

The combination of ingredients provide synergy (one bronchodilator, four vasodilators, and the potent sex steroid hormone testosterone) that can improve female libido (sex drive) and sexual enjoyment. Libido Cream is designed to act locally without substantial absorption into the bloodstream.

Androgens are hormones that play an important role in sex. Your doctor may prescribe an androgenic hormone like testosterone or DHEA to supplement low hormone levels and improve sexual function.

Testosterone is available in different forms depending on patient preference. Options include: 

  • Subcutaneous pellet 
  • Injection 
  • Nasal gel 
  • Topical cream


Read more about testosterone therapy

Oxytocin injections or infusions are used to induce labor in pregnant women. However, there is a growing interest in oxytocin use for the treatment of FSD and HSDD. (The FDA has not approved oxytocin for treating these disorders.)

Oxytocin is naturally released from the brain in men and women to help regulate anxiety, stress-coping, and various social behaviors.

However, lower doses of oxytocin can also be used sublingually (under the tongue) or intranasally (in the nose) off-label to increase sociability, maternal behavior, and to increase desire and response.

Sildenafil citrate is a phosphodiesterase type-5 (PDE5) inhibitor that is typically used for the treatment of male erectile dysfunction. Sildenafil citrate has been reported to produce increases in vaginal blood flow.

Since the approval of sildenafil citrate by the US FDA in 1998, hundreds of articles regarding the safety and efficacy of sildenafil citrate for male erectile dysfunction have been published; however, only a handful of randomized trials have assessed the use of sildenafil citrate in women with arousal disorder.

Phosphodiesterase type-5 receptors are present in vaginal, clitoral and labial smooth muscle, and sildenafil citrate can relax clitoral tissue. Evidence from randomized controlled trials shows that sildenafil citrate is moderately effective in treating arousal disorder. Sildenafil citrate may be effective in patients with arousal disorder secondary to multiple sclerosis, diabetes or antidepressant use; however, more trials in these patient populations are required to confirm current findings. Sildenafil citrate has a good safety profile in both women and men.

Vyleesi™, the brand name for bremelanotide, is typically used to treat HSDD. Defy Medical offers affordable bremelanotide options for patients with limited access to the brand name prescription. 

Read more about bremelanotide

PRP is a non-invasive, in-office medical procedure designed to improve arousal and physical responses to stimulation and/or penetration. 

Read more about PRP Injection therapy

There are topical creams designed for vaginal application that contain androgenic hormones similar to testosterone but with different effects.

Treatment may involve one or more therapies. It may be necessary to treat desire, arousal, and orgasm as separate conditions, or a combination thereof.

Are You An International Patient?
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Options for patients who reside outside of the U.S.

If you live in the United Kingdom, Canada, or another country outside of the U.S. and you're looking for guidance on female sexual dysfunction and hormone restoration therapy – Defy Medical can help you. Our International Consultations allow you to talk with an expert to receive informed recommendations on care.

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