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The Top 12 Treatments for Chronic Stress

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Chronic stress can have many negative effects throughout the body. If you’ve been going through long periods of stress without a break, you may be experiencing chronic stress.

You can utilize supplements and medications for support with chronic stress. Below are twelve products (plus one lab test) that may be able to help you cope with the ongoing stress in your life.

Cortisol Salivary Test

A salivary cortisol test can be a good place to start if you think you have chronic stress. This test includes four separate measurements of your cortisol levels, taken at various times throughout the day. This is considered to be the most accurate measurement of cortisol levels.

Cortisol is a steroid hormone produced by the adrenal glands during times of stress. Measuring your cortisol levels can help you identify if you’re experiencing chronic stress, along with other potential conditions like adrenal distress.

Oxytocin ODT

Oxytocin is a foundational peptide used in wellness to improve life quality. It is released naturally during childbirth and sex, and it’s thought to help form social bonds and increase enjoyment in social interactions. Learn more about Oxytocin and what it’s commonly used for.

Supplementing oxytocin can help lift mood and alleviate anxiety and depression, which are common stress symptoms. This is why oxytocin is one of the common treatments for chronic stress.

Oxytocin may help with:

  • Depression, depressed mood (chronic, cyclic, or periodic)
  • Generalized anxiety
  • Low libido or hypoactive desire
  • Social anxiety
  • Compulsive or addictive behavior
  • Low energy (mental fatigue)
  • General wellness

Defy Medical can prescribe Oxytocin when appropriate. Oxytocin comes in the form of an oral disintegrating tablet, which dissolves in 60 seconds without water.

B12 (Methylcobalamin) Injections

If you’re experiencing high stress and anxiety levels, B12 can help elevate your mood. Injectable B12, also called Methylcobalamin, can be used to improve mood and energy while supporting metabolism and boosting the immune system.

In the body, B12 is involved in the metabolism of cells, fatty acid synthesis, DNA synthesis and regulation, energy production, and more.


Supplementing with B-Complex can help you cope with stress. The different B vitamins include:

  • Thiamin (vitamin B-1)
  • Riboflavin (vitamin B-2)
  • Niacin (vitamin B-3)
  • Pantothenic acid (vitamin B-5)
  • Vitamin B-6
  • Biotin (vitamin B-7)
  • Folate (vitamin B-9)

These essential nutrients benefit the body in many ways, including supporting heart health and energy production, promoting healthy nerve cells and the formation of neurotransmitters, and assisting in the creation of red blood cells.


This injectable nutrient is a powerful antioxidant, and it may help you combat some of the damage caused by stress. L-Glutathione is made up of the amino acids L-glutamate, L-cysteine, and glycine.

The benefits of L-glutathione may include:

  • Boosting the immune system
  • Assisting the body with metabolizing toxins
  • Repairing damaged cells (including cells damaged by stress, pollutions, toxins, and more)
  • Detoxifying the liver
  • Fighting free radicals


PS-100, or Phosphatidylserine 100mg, is important in maintaining overall cellular function. Supplementing with PS-100 can help lower cortisol levels, which can ease the symptoms of chronic stress and improve sleep patterns. It can also help maintain a normal heartbeat, memory pathways, and hormone secretion.

Overall, PS-100 can be a powerful tool in coping with chronic stress.

Magnesium Capsules

Stress can deplete the body’s magnesium stores, which is unfortunate – because magnesium is an important anti-stress mineral. Magnesium can help relax the muscles, and it is often used as a natural supplement to help ease anxiety.

Magnesium helps support neural health, as well, and it also supports the hypothalamus, pituitary glands and adrenal glands, which regulate the body’s stress response.

5-HTP Capsules

5-Hydroxy-L-Tryptophan, or 5-HTP, helps regulate your body’s serotonin levels in the central nervous system and the brain. This compound is created by the body from tryptophan, and it’s a precursor in the biosynthesis serotonin and melatonin.

5-HTP plays an important function in mood regulation, the sleep cycle, managing anxiety, and more. Supplementing with 5-HTP while experiencing chronic stress may help ease stress symptoms.

REM Maintenance Powder

Stress can interrupt your sleep cycle, and repeated lack of sleep can put you at a higher risk of heart disease, diabetes, and other issues.

REM Maintenance Powder is a combination of nutrients that help support healthy, natural sleep. Ingredients include:

  • Glycine, which helps suppress muscle twitches in REM sleep and decrease core temperature.
  • Magnesium and potassium, which act as natural muscles relaxers.
  • Inositol, which can regulate the nervous system and help calm anxiety.
  • 5-Hydroxytryptophan (5-HTP), which helps regulate the body’s serotonin and melatonin levels.
  • Melatonin, which acts as a natural sleep aid.

Stress Maintenance

This supplement is designed to help ease anxiety and reduce stress. It contains gamma-Aminobutyric acid (GABA) and the botanical Primula Veris, which work together to help activate GABA receptor. This receptor is a neurotransmitter that can help decrease activity within your nervous system – which can have a calming effect.

This supplement also contains addition ingredients for a calm and relaxing effect:

  • Glycine
  • Glutamine
  • Passionflower
  • Magnesium


DHEA (Dehydroepiandrosterone) is considered the “mother hormone” because it’s a precursor to androgens and estrogens – male and female sex hormones.

Chronic stress and ongoing illness can put pressure on the adrenal glands, which are typically the body’s major internal source of sex hormones as we age. When we experience adrenal insufficiency, it can have many negative effects throughout the body.

That’s why DHEA can be prescribed as one of the treatments for chronic stress, to help counteract those negative effects. It is commonly prescribed to help:

  • Boost energy
  • Bolster the immune system
  • Increase strength
  • Promote fat loss
  • Treat lupus, multiple sclerosis, and Alzheimer’s disease


Pregnenolone is sometimes thought to be the “father” of hormones, because it is the starting hormone from which all other hormones are made.

Providers sometimes recommend supplementing with pregnenolone to help with:

  • Energy levels
  • Memory and mentally clarity
  • Overall health and well-being
  • Vision

Because chronic stress can impact mood, memory, and other bodily functions, Pregnenolone may be a good supplement to help combat these effects.

DHEA and Pregnenolone can also be supplemented together as treatments for chronic stress, depending on the needs of the patient.

Stress Management with Defy Medical

Interested in effective treatments for chronic stress? Defy Medical offers access to high-quality supplements  that can help you more effectively manage cortisol and chronic stress.

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