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Tri-Amino Injections: A Potential Relief for Migraines

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Textbook illustration showing pain caused from a headache.

Tri-amino injections include three amino acids: L-Arginine, L-Citrulline, and L-Ornithine.

Together, these amino acids can encourage the production of Nitric Oxide (NO), a vasodilator. NO expands the blood vessels and increases blood flow, which can offer relief from migraines.

Read on to learn more about how these amino acids may help with your migraine symptoms.

What is a Migraine?

A migraine is more than a headache. It’s a pulsing or throbbing pain that typically happens on one side of the head. It may start over one eye, or radiate pain throughout the forehead.

In addition to head pain, Migraines are typically accompanied by other symptoms:

  • Auras floating over your vision
  • Blurry or distorted vision
  • Nausea and vomiting
  • Sensitivity to light and sound
  • Neck stiffness or pain

A migraine can last for hours or even days, and it’s disruptive to the lives of those who suffer from them. You may need to rest in bed and avoid triggers for the rest of the (or days), which can be difficult if you have a busy or active lifestyle.

There are prescription medications available to treat migraines, but these often come with side effects or cannot be taken every day. Tri-amino is a potential non-prescription solution for migraines.

What Causes Migraines?

The exact cause of migraines is unknown.

Migraines seem to be caused by a response to serotonin, which is a neurotransmitter responsible for many functions.

High serotonin levels cause blood vessels to contract, while low serotonin levels can cause them to dilate. This change seems to trigger swelling and pain in the blood vessels around the forehead.

Migraines may also be related to electrical or chemical activity throughout the brain.

While the exact physiological cause is unknown, migraines typically have documented triggers that can bring them on. These include:

  • Stress
  • Hormone fluctuations
  • Missing sleep or changing your sleep schedule
  • Coffee and other caffeine stimulants
  • Alcohol
  • Changes in the weather
  • Changes to your diet
  • Sensory triggers like light, sounds, and smell
  • Dehydration
  • Certain medications

Triggers are very individual, and what affects one person may not affect another. If you’re not sure of your triggers, start keeping a migraine diary to document what potential triggers you were exposed to prior to the onset of a migraine.

L-Arginine for Migraines

L-Arginine is one of the amino acids in Tri-Amino injections. It’s a chemical precursor to Nitric Oxide, or NO, and one of its main functions is to support the production of NO.

NO dilates the smooth muscle of the blood vessels, which improves blood flow and decreases blood pressure. Because migraines are often caused by painful shrinking and swelling in the blood vessels around the head, NO may help soothe this pain.

Its direct effect on NO is why L-arginine can be a treatment for migraines.

L-Citrulline and L-Ornithine for Migraines

Both L-Ornithine and L-Citrulline also affect NO levels in the body.

L-Citrulline can be converted to L-Arginine in the kidneys, which is one way it works to increase the production of NO.

In addition to migraine relief, L-Citrulline has shown promise in reducing blood pressure and treating mild erectile dysfunction.

L-Ornithine is a precursor to L-Citrulline, as well as Glutamic acid and proline. L-Ornithine may also increase L-Arginine levels to boost NO levels in the body.

In addition to helping with migraine pain, L-Ornithine has demonstrated benefit in boosting athletic performance due to the way it decreases ammonia levels in the blood.

Tri-Amino for Migraines

All three amino acids in Tri-amino are closely linked and work together throughout the urea cycle, which is why Tri-amino injections can lead to positive effects.

Many patients report almost instant relief of their migraines when they take Tri-Amino upon the first onset of symptoms.

Depending on the cause of the migraine or headache, Tri-Amino can increase nitric oxide which will enhance blood flow to the brain and potentially provide quick relief from migraine pain.

Learn about other benefits of Tri-Amino injections. 

Nutrition Injections from Defy Medical

Defy Medical offers a range of injectable nutrients to help you optimize your wellness. This includes Tri-amino injections, which are a potential treatment for migraines.

Once you become a Defy Medical patient, you can order injectable nutrition and other supplements easily online via our Patient Portal, with direct-to-door delivery.

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