Find the root cause of your symptoms with Defy Medical.
"Why do I feel this way?"
Feeling a decline in drive, energy, and libido? Defy Medical uses in-depth consultations, comprehensive blood testing, and a decade of experience to develop customized treatments via telemedicine.
Feel better. Defy expectations.
Defy Medical
The World’s Leading Hormone Replacement Clinic
Defy Medical has guided thousands of patients to living healthier, happier lives – and we’re ready to help you. Our experienced care team specializes in hormone restoration and integrative therapies designed to help you feel better.
Get Started
Wondering if HRT is right for you?
Take our 3-minute quiz to see if you may be a candidate for Hormone Replacement Therapy.
This quiz is meant to provide guidance and is not intended to be medical advice. Blood testing and consulting with a knowledgeable provider are required to diagnose hormone deficiency.
Take the Quiz
Some of Our
Core Services
For Men
Testosterone Replacement Therapy
Optimize your levels and performance with a customized treatment plan for low Testosterone (hypogonadism).
Erectile Dysfunction
Regain satisfaction with your sex life and enhance your sexual performance. Find effective and affordable therapies for erectile dysfunction.
For Women
Hormone Therapy
Combat the effects of hormone imbalance and regain your zest for life with Bioidentical Hormone Replacement Therapy (BHRT).
Sexual Dysfunction
Enhance intimacy with treatments designed to boost libido, improve sensation, and ease pain during intercourse.
Meet our Care Team
Led by Medical Director Dr. Justin Saya, our care team has extensive experience in hormone restoration, sexual health treatment, and integrative wellness. They’re passionate about helping patients improve their lives and feel their best.
See Our ProvidersWhat Our Patients are Saying
Showing our most recent 4- & 5-star reviews.
See All 2729 Reviews on
“Dr Calkins is very knowledgeable”
Visited on October 3, 2024
Dr Calkins is very knowledgeable, patient and answered all my questions. I am very pleased with my consultation and look forward for improvement in my health.
–ZHANNA T
“Thorough”
Visited on October 4, 2024
Marisa provided a thorough analysis of my bloodwork and made several very good recommendations. Explained things with clear explanations and took the time to do so.
–Tom H.
“Caleb was amazing!”
Visited on October 3, 2024
Caleb was amazing!! My case is a little complex due to some medical history. He explained more to me than any doctor I have seen in the past ten years. I couldn’t thank him enough.
–BONNIE CARROLL
“This is top tier care”
Visited on October 1, 2024
This is top tier care, I couldn’t ask for better.
I would be very interested in having my TRT care switched from my current provider, to defy. I simply would need a total cost for treatment.
–FREDRICK WEST
“Janel is always professional and caring.”
Visited on October 2, 2024
Janel is always professional and caring.
–MARGARET TIERNEY
“Michael is a fantastic provider”
Visited on October 4, 2024
Michael is a fantastic provider. His constant research and personal experience with the care options gives him the credibility and insight I rely on for the best possible results.
–MORGAN PORTER
“Beth is amazing.”
Visited on October 1, 2024
Beth is amazing. She is a truly gifted medical professional who really has the patient’s best at heart. I sincerely appreciate not only how knowledgeable and competent she is, but the empathy and kindness she shows us. Thanks for everything, you’ve made a huge difference in my quality of life.
–Nate R
“Jill listened and understood”
Visited on October 1, 2024
Jill listened and understood my frustrations and health journey. I am hoping with her guidance that my quality of life will continue to improve.
–TERESA MCLAREN
“Janel is an exceptional medical provider”
Visited on October 1, 2024
Janel is caring, personable and very knowledgable. The consultation didn’t feel awkward or rushed, it felt as if I was talking to an old friend. Her recommendations made sense and she reiterated multiple times that it’s ok for me to reach out if HRT protocol is giving me trouble. A genuine medical professional that is truly a needle in a haystack. We need more providers like her!
–AGNE SOLOMON
“Attentive!”
Visited on October 1, 2024
He was attentive and listened to my health goals and concerns.
–GERARD RICHARDS
News and Health Articles
Learn more about integrative therapies, hormone restoration, and more.
See More Articles
Do You Gain Weight After Stopping Semaglutide?
Semaglutide is rising in popularity as a prescription weight loss tool. But what happens when you stop taking semaglutide?
Learn More About Do You Gain Weight After Stopping Semaglutide?
Are GLP-1 Agonists the Secret to Weight Loss?
GLP-1 agonists like Semaglutide impact blood sugar and support metabolic health. Recently, they've shown promise in helping with weight loss.
Learn More About Are GLP-1 Agonists the Secret to Weight Loss?
What is Liraglutide?
Liraglutide is a GLP-1 agonist that can help with blood sugar management and weight loss. Learn more about how Liraglutide works.
Learn More About What is Liraglutide?