Find the root cause of your symptoms with Defy Medical.
"Why do I feel this way?"
Feeling a decline in drive, energy, and libido? Defy Medical uses in-depth consultations, comprehensive blood testing, and a decade of experience to develop customized treatments via telemedicine.
Feel better. Defy expectations.
The World’s Leading Hormone Replacement Clinic
Defy Medical has guided thousands of patients to living healthier, happier lives – and we’re ready to help you. Led by Medical Director Dr. Justin Saya, our expert care team specializes in hormone restoration and integrative therapies designed to help you feel better.Get Started
Wondering if HRT is right for you?
Take our 3-minute quiz to see if you may be a candidate for Hormone Replacement Therapy.
This quiz is meant to provide guidance and is not intended to be medical advice. Blood testing and consulting with a knowledgeable provider are required to diagnose hormone deficiency.Take the Quiz
Some of Our
“Working with Defy has been the best decision I've ever made...”
Dr. Saya and team have been a godsend for me. Other doctors have brushed me off, saying my labs were in ‘normal’ range, but never listened to the symptoms I was suffering from. Working with Defy has been the best decision I’ve ever made, and I’ll continue to recommend them to others.
“I no longer have the hot flashes (YES!), and my moods are even...”
[My husband and I] have been seeing Dr. Saya, and now Jill, for several years now. I even switched my thyroid care to them as well. I no longer have the hot flashes (YES!), and my moods are even, no extreme mood swings. Thank goodness!
“I want to thank Dr. Calkins from the bottom of my heart.”
No doctor in my town wanted to treat me because I was only 25, despite having diagnosis, imaging and bloodwork indicating I needed the help. I want to thank Dr. Calkins from the bottom of my heart. The past few months have been so liberating for me and I finally feel in control of my life. Also, for the first time in my life, I can truly say I’m happy. I’m not just going through the motions to get through the day anymore.