Find the root cause of your symptoms with Defy Medical.
"Why do I feel this way?"
Feeling a decline in drive, energy, and libido? Defy Medical uses in-depth consultations, comprehensive blood testing, and a decade of experience to develop customized treatments via telemedicine.
Feel better. Defy expectations.
Defy Medical
The World’s Leading Hormone Replacement Clinic
Defy Medical has guided thousands of patients to living healthier, happier lives – and we’re ready to help you. Our experienced care team specializes in hormone restoration and integrative therapies designed to help you feel better.
Get Started
Wondering if HRT is right for you?
Take our 3-minute quiz to see if you may be a candidate for Hormone Replacement Therapy.
This quiz is meant to provide guidance and is not intended to be medical advice. Blood testing and consulting with a knowledgeable provider are required to diagnose hormone deficiency.
Take the Quiz
Some of Our
Core Services
For Men
Testosterone Replacement Therapy
Optimize your levels and performance with a customized treatment plan for low Testosterone (hypogonadism).
Erectile Dysfunction
Regain satisfaction with your sex life and enhance your sexual performance. Find effective and affordable therapies for erectile dysfunction.
For Women
Hormone Therapy
Combat the effects of hormone imbalance and regain your zest for life with Bioidentical Hormone Replacement Therapy (BHRT).
Sexual Dysfunction
Enhance intimacy with treatments designed to boost libido, improve sensation, and ease pain during intercourse.
Meet our Care Team
Led by Medical Director Dr. Justin Saya, our care team has extensive experience in hormone restoration, sexual health treatment, and integrative wellness. They’re passionate about helping patients improve their lives and feel their best.
See Our ProvidersWhat Our Patients are Saying
Showing our most recent 4- & 5-star reviews.
See All 3951 Reviews on
“Doctor was knowledgeable helpful and…”
Visited on July 17, 2026
Doctor was knowledgeable helpful and had some good insight. It’s been like 2 months since I started this process though so I hope the medicine gets prescribed soon. Trying to get rid of pain and until I get things going I just have to put up with it. Other than that you guys have been great:-)
–JOSLIN,SERGEI
“1st consult with Doc”
Visited on July 16, 2026
1st consult with Doc. So far so good.
–YOHEY,VICTOR
“Amazing experience so far!”
Visited on July 17, 2026
So far my experience has been amazing! The provider was very thorough and listened to everything i was concerned about. It was very easy to talk to her as well she was very personable!
–RIECK,JESSICA
“Mike was very helpful on explaining my…”
Visited on July 16, 2026
Mike was very helpful on explaining my blood work results and covering what I needed to improve some of the markers
–GUERRERO,ALEJANDRO
“Dr Calkin was incredible”
Visited on July 18, 2026
Dr Calkin was incredible. He explained how each hormone imbalance would make me feel with real life (and funny) examples. He gave me an action plan that is flexible depending on how I feel. He aas so easy to bounce ideas off of and I really felt like he cared. Tysm!!
–ISGATE,DONNA
“Professional”
Visited on July 18, 2026
Professional, Informative, and Helpful
–HIGHTOWER,TIMOTHY
“Great but slow start”
Visited on July 17, 2026
was great! lost connection but Megan called me on my phone to finish up. The process the uploading process seems to be taking a long time. I’m hoping it will be worth the wait.
–GRIFFITH,JEFF
“Good discussion”
Visited on July 19, 2026
Good discussion, sensible questions, knowledgeable answers
–EDWARD
“Morgan is a wonderful PA!”
Visited on July 16, 2026
Morgan is a wonderful PA!
–BALOW,HANNAH
“His knowledge and understanding in what…”
Visited on July 18, 2026
His knowledge and understanding in what I want to accomplish.
–customer
News and Health Articles
Learn more about integrative therapies, hormone restoration, and more.
See More Articles
FDA to Remove Outdated Warnings on BHRT Medications
The FDA announced that it will remove black box warnings from BHRT estrogen products. These warnings are based on outdated research.
Learn More About FDA to Remove Outdated Warnings on BHRT Medications
Why Patients Choose Defy Medical Over Other Hormone Clinics
Defy Medical has been offering comprehensive, expertly guided hormone therapy and concierge care since 2011.
Learn More About Why Patients Choose Defy Medical Over Other Hormone Clinics
Do You Gain Weight After Stopping Semaglutide?
Semaglutide is rising in popularity as a prescription weight loss tool. But what happens when you stop taking semaglutide?
Learn More About Do You Gain Weight After Stopping Semaglutide?