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Find the root cause of your symptoms with Defy Medical.

"Why do I feel this way?"

Feeling a decline in drive, energy, and libido? Defy Medical uses in-depth consultations, comprehensive blood testing, and a decade of experience to develop customized treatments via telemedicine.

Feel better. Defy expectations.

Defy Medical

The World’s Leading Hormone Replacement Clinic

Defy Medical has guided thousands of patients to living healthier, happier lives – and we’re ready to help you. Our experienced care team specializes in hormone restoration and integrative therapies designed to help you feel better.

Get Started
Man and woman taking the Defy Medical quiz on their laptop.

Wondering if HRT is right for you?

Take our 3-minute quiz to see if you may be a candidate for Hormone Replacement Therapy.

This quiz is meant to provide guidance and is not intended to be medical advice. Blood testing and consulting with a knowledgeable provider are required to diagnose hormone deficiency.

Take the Quiz

Some of Our

Core Services

For Men

Learn MoreA man smiles as he runs near a bridge and body of water, showing the benefits of Testosterone Replacement Therapy online.

Testosterone Replacement Therapy

Optimize your levels and performance with a customized treatment plan for low Testosterone (hypogonadism).

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Learn MoreA black man hugs his partner, a black woman, as they smile because they successfully treated erectile dysfunction (ED).

Erectile Dysfunction

Regain satisfaction with your sex life and enhance your sexual performance. Find effective and affordable therapies for erectile dysfunction.

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For Women

Learn MoreA mature woman sits on a couch smiling in a yellow sweater, showing the success of her hormone therapy.

Hormone Therapy

Combat the effects of hormone imbalance and regain your zest for life with Bioidentical Hormone Replacement Therapy (BHRT).

Learn More
Learn MoreA man and woman smile at the camera as the woman hugs the man from behind, celebrating their treatment of female sexual dysfunction.

Sexual Dysfunction

Enhance intimacy with treatments designed to boost libido, improve sensation, and ease pain during intercourse.

Learn More

Meet our Care Team

Led by Medical Director Dr. Justin Saya, our care team has extensive experience in hormone restoration, sexual health treatment, and integrative wellness. They’re passionate about helping patients improve their lives and feel their best.

See Our Providers

What Our Patients are Saying

Showing our most recent 4- & 5-star reviews.

TrustScore 5 out of 5 See All 269 Reviews on Trustpilot

Read More Patient Stories

“Mike was very thorough and took the…”

Visited on September 23, 2022

Mike was very thorough and took the time to explain everything in detail.

–Verified Buyer

5 out of 5

“Mike was very attentive”

Visited on September 20, 2022

Mike was very attentive, informative, and really listened. He has a very high level of expertise and interpreted my lab results clearly and thoroughly. He didn’t rush me through the consult and was very patient with answering all of my questions.


5 out of 5

“Janel listened to all my concerns and…”

Visited on September 22, 2022

Janel listened to all my concerns and asked follow up questions so that she could fully understand my situation. She was great at explaining the plan forward and what to expect, the good and the possible bad symptoms, and when/how to contact her next if I had any issues


5 out of 5

“Jill was great”

Visited on September 22, 2022

Jill was great, answered all my questions and made suggestions


5 out of 5

“Jill is amazing and I am so happy to…”

Visited on September 22, 2022

Jill is amazing and I am so happy to have her in my side helping me with my fitness goals.


5 out of 5

“Very knowledgeable and easy to speak…”

Visited on September 24, 2022

Very knowledgeable and easy to speak with great experience


5 out of 5

“Defy consultation”

Visited on September 23, 2022

I really enjoyed my consultation with Beth. She discussed my recent blood panel results. She advised me on necessary actions to take on the results that were not in the normal range.


5 out of 5

“Defy Medical”

Visited on September 22, 2022

Process was smooth. Bloodwork is reasonably affordable. Melissa was really nice and easy to talk to.


5 out of 5

“Dr. Calkins”

Visited on September 22, 2022

Dr. Calkins was very patient, thorough, and addressed all of my concerns. Everything was explained in plain language. Because I switched my treatment from my primary care physician to Defy, my journey with Defy started slightly different than many others. The switch over was relatively seamless and I got to spend more time with Dr. Calkins discussing my treatment than I’ve ever had with a doctor as a patient. I’m grateful for the help and expertise!


5 out of 5

“Greta insightful experience with Ben”

Visited on September 22, 2022

Greta insightful experience with Ben. Very helpful!


5 out of 5