A published review of studies attempted to determine, from published studies, the time-course of the effects induced by testosterone replacement therapy from their first manifestation until maximum effects are attained.

This review found that:

  • Effects on sexual interest appear after 3 weeks plateauing at 6 weeks, no further increments beyond. 
  • Changes in erections/ejaculations may require up to 6 months. 
  • Effects on quality of life manifest within 3-4 weeks, but maximum benefits take longer. 
  • Effects on depressive mood appear after 3-6 weeks with a maximum after 18-30 weeks. 
  • First effects on erythropoiesis (increased red blood cells) after 3 months, peaking at 9-12 months. 
  •  Prostate specific antigen and volume rise, marginally, plateauing at 12 months; further increase related to aging rather than therapy. 
  • Effects on lipids appear after 4 weeks, maximal after 6-12 months. Insulin sensitivity may improve within few days, but effects on glycemic control become evident only after 3-12 months. 
  • Changes in fat mass, lean body mass and muscle strength occur within 12-16 weeks, stabilize at 6-12 months, but marginally continue to improve over years. Effects oninflammation occur within 3 to 12 weeks. 
  • Effects on bone detectable after 6 months but continue at least for 3 years.


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For information on how to prevent or reverse side effects of testosterone, click here:

Testosterone Side Effect Management Table