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Ever since human growth hormone (HGH) was first titled The Fountain of Youth, researchers have studied the phenomenon that occurs when a hormonally deficient person is given physiological doses, and seems to rapidly decrease in biological age.
It wasn't until 1997 that growth hormone deficiency was recognized as a clinical syndrome. "Growth hormone deficiency is now formally recognized as a specific clinical syndrome, typified by decreased muscle mass, increased body fat, decreased exercise capacity, osteopenia, abnormal lipid profiles and diminished feeling of well being…" (Inzucchi, Silvo; Hospital Practice, Jan. 15,1997).
Growth Hormone Releasing Hormone (GHRH), also known as Sermorelin Acetate, is an FDA approved medication which is used to safely increase the production of Growth Hormone. Sermorelin works by stimulating the pituitary gland to increase levels of growth hormone to be released throughout the day and night.
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Among the many positive effects Sermorelin has on the human body, improved brain function seems to occur within a short time after administration.
The effect that growth hormone can have on the brain can best be observed in patients who produce little or no growth hormone as a result of pituitary tumors, or the complete removal of the pituitary gland where growth hormone is produced. No matter the age of the patient, they all seem to exhibit the same psychological effects due to lack of growth hormone; decreased work capacity, depression, increased social isolation, mood swings and anxiety (Klatz, Dr. Ronald; Goldman, Dr. Robert; Stopping the Clock 2003).
In 2000, Swedish scientists discovered that growth hormone acts as an anti-depressant in the brain, raising the level of B-endorphin, the brains natural opiate. This increase in B-endorphin was complimented by a decrease in dopamine, which results in a reduction in feelings of agitation. Another study, conducted by the Dutch, found "GH deficiency was directly related to impairments in ability to process a flash of information (iconic memory), short-term memory, long-term memory and perpetual motor skills such as hand-eye coordination". ( Klatz, Dr. Ronald; Goldman, Dr. Robert; Stopping the Clock 2003) .
A 1998 report showed that depressed men secrete much less GH during the first 3 hours of sleep than non-depressed individuals. It is during our sleep that we produce the majority of our growth hormone. These studies, in addition to reports from men and women who increase their GH levels using Sermorelin, prove that this powerful hormone greatly affects the human brain in a positive way. As we age, and our hormone levels decrease, we may find that Sermorelin therapy alleviates many of the symptoms of biological aging. There is also some hope that Sermorelin and similar peptides will eventually be used in mainstream medicine to treat various diseases such as depression, Alzheimer's and Parkinson's.