For First Time, Researchers Analyze Levels of Testosterone and Estradiol to Predict Patients' Likelihood of Suffering Usually Fatal Condition, Take Another Step Toward Offering Preventive Treatments

 

Los Angeles - Sept. 2, 2014 – Measuring the levels of sex hormones in patients' blood may identify patients likely to suffer a sudden cardiac arrest, a heart rhythm disorder that is fatal in 95 percent of patients.

A new study, published online by the peer-reviewed journal Heart Rhythm, shows that lower levels of testosterone, the predominant male sex hormone, were found in men who had a sudden cardiac arrest. Higher levels of estradiol, the major female sex hormone, were strongly associated with greater chances of having a sudden cardiac arrest in both men and women.

"Because sudden cardiac arrest is usually fatal, we are constantly looking for ways to predict which patients are susceptible so we can concentrate on prevention," said Sumeet Chugh, MD, director of the Heart Rhythm Center in the Cedars-Sinai Heart Institute and the Pauline and Harold Price Chair in Cardiac Electrophysiology Research. "If we wait until someone has a sudden cardiac arrest, it is usually too late for treatment."

We have selected a few abstracts from studies done on the effects of low testosterone, and testosterone supplementation in women. Sometime referred to as “the hidden disease”, low testosterone in women has been overlooked mainly due to testosterone being viewed primarily as a “male hormone”. Women have testosterone too, although in smaller amounts than men, but this small amount is necessary for many important functions highlighted in the studies below. The potential side effects listed within many of these studies as a concern are acne and facial hair growth (hirsutism) but we know that this can be mitigated with proper dosing. If acne or facial hair growth occur, typically this means the testosterone is dosed too high. Proper dosing will not produce these effects.

DHEA: What do the studies show?

DHEA is a steroid prohormone produced by the adrenal glands and transformed in target tissue through intracrine mechanisms to androgens or estrogens. Plasma DHEA levels decline with age. By the age of 70–80 years, levels may be as low as 10%–20% of those encountered in young individuals.

The importance of DHEA in steroid hormone production increases with age. Indeed, in postmenopausal women, production of estrogens by the ovaries declines dramatically, making the adrenals the only source of steroid hormones through DHEA. In men, although T secretion by the testicles continues late into life, T levels progressively decline, and DHEA’s importance in steroid hormone production is also higher with increasing age. DHEA’s effect is mostly through its hormone end products.

Monica Bawor,Brittany B. Dennis,M. Constantine Samaan,Carolyn Plater,Andrew Worster,Michael Varenbut,Jeff Daiter,David C. Marsh,Dipika Desai, Meir Steiner, Rebecca Anglin, Margaret Coote, Guillaume Pare, Lehana Thabane & Zainab Samaan

Scientific Reports 4, Article number: 6189 doi:10.1038/srep06189 Received 30 April 2014 Accepted 06 August 2014 Published 26 August 2014

Sex hormones may have a role in the pathophysiology of substance use disorders, as demonstrated by the association between testosterone and addictive behaviour in opioid dependence. Although opioid use has been found to suppress testosterone levels in men and women, the extent of this effect and how it relates to methadone treatment for opioid dependence is unclear. The present multi-centre cross-sectional study consecutively recruited 231 patients with opioid dependence from methadone clinics across Ontario, Canada between June and December of 2011. We obtained demographic details, substance use, psychiatric history, and blood and urine samples from enrolled subjects.

We do not agree with adding a black box warning on testosterone products. This is why:

A study recently published that concluded that testosterone replacement therapy (TRT) can increase the risk of heart attacks in men shed lights on what happens when older men are given TRT without managing blood levels of certain well-known factors that can potentially affect their health. Men volunteering for this study, seeking to regain their vitality, were exposed to higher risks due to negligence and lack of compliance by researchers to current medical guidelines.

When it comes to building muscle and burning body fat, maximizing testosterone and growth hormone levels seems to be the primary focus among fitness athletes. Without optimal levels of these key hormones we would see a decrease in lean muscle tissue and increase in fat deposits throughout the body. But there is something missing in this equation, there are many other factors within the body that come into play when it comes to achieving your physique goals. It is within the synergy of other hormones and hormone mediators besides HGH and testosterone that we can see ourselves mold into works of art.

By ANAHAD O'CONNOR
July 14, 2014

For decades, millions of men with early prostate cancer have been placed on drug therapy to suppress their production of testosterone, despite such significant side effects as impotence, diabetes and bone loss. Now a large new analysis has concluded that so-called androgen deprivation therapy does not extend the lives of these patients.

“There are so many side effects associated with this therapy, and really little evidence to support its use,” said Dr. Grace L. Lu-Yao, a researcher at the Rutgers Cancer Institute of New Jersey and the lead author of the report, published on Monday in JAMA Internal Medicine. “I would say that for the majority of patients with localized prostate cancer, this is not a good option.”

Vitamin D3: A new way to take D3 and save money.

More people have become aware of the research which supports the benefits of maintaining good D3 levels in the blood.  In addition, the majority of patients we see are on the low end of the range when D3 levels are tested.  WebMD states that vitamin D deficiency is more common than we thought.  Many people are too busy to get outside to get enough sunlight, a primary source for D3, not to mention have the motivation to add yet another daily taken pill/capsule to their lives.

AlterNet / By Martha Rosenberg

No one should have to choose between their hairline and their health. But increasingly, men who use finasteride, commonly known as Propecia, to treat their male pattern baldness are making that choice, often unwittingly. In the 17 years since Propecia was approved to treat hair loss from male pattern baldness, many disturbing side effects have emerged, the term post-finasteride syndrome (PFS) has been coined and hundreds of lawsuits have been brought.

Finasteride inhibits a steroid responsible for converting testosterone into 5α-dihydrotestosterone (DHT) the hormone that tells hair follicles on the scalp to stop producing hair. Years before Propecia was approved to grow hair, finasteride was being used in drugs like Proscar, Avodart and Jalyn to treat an enlarged prostate gland (benign prostatic hyperplasia).

Testosterone prescriptions for older men in the United States have increased more than three-fold over the past decade. Recent studies linking testosterone use with increased risk of heart attack and stroke have caused widespread concern among patients and their families. A new U.S.-based study of more than 25,000 older men shows that testosterone therapy does not increase men's risk for heart attack.

The study, conducted by researchers at the University of Texas Medical Branch at Galveston, examined 25,420 Medicare beneficiaries 66 years or older treated with testosterone for up to eight years. It appears in the July 2 issue of the Annals of Pharmacotherapy.

During the last year we have had an increase in reports from men that they are running out of their testosterone cypionate injections before the refill date. Lets first rule out those who over-draw the testosterone into the syringe, of course we must pay attention to detail when in comes to lining up the syringe plunger with the dosage line. If we are not paying attention, or have not been instructed properly, over drawing just a small amount of testosterone at each injection can lose 1 milliliter or more. There are other factors which can cause loss of testosterone as you inject regularly. If you notice at the base of your needle, where you attach the needle to the syringe, there is empty space which can trap the testosterone even after depressing the plunger completely. There always seems to be that little bit of T that will not leave the syringe/needle. In addition to the T being trapped in the needle head, there is also a small amount of T left behind on the syringe walls. This type of loss is unavoidable when using a 3ml or larger syringe. Over the course of 10-20 injections using a 10ml multi-dosed bottle that little bit of lost T adds up.

testosterone over 550 ng/dL reduced the risk of cardiovascular events

In a revealing new study, researchers identified 2,416men (aged 69-81 years) who were not on any kind of testosterone- affecting treatment. These men were subjected to a battery of blood tests that included total testosterone and estradiol (estrogen). 

The first observation was that men with increasing levels of testosterone had a decreased prevalence of diabetes, hypertension, and body fat mass. Compared to men with the highest testosterone levels, those with low testosterone were twice as likely to have a history of cardiovascular disease. It was also observed that men with the highest testosterone levels were the most physically active. 

(Penguin/Avery Sept 2007) by Jacob Teitelbaum MD.

Before we begin the SHIN protocol, however, let’s jump-start our energy and set ourselves up for success.

Jump-Starting Your Body’s Energy Furnaces

As we will discuss throughout this book, CFS and fibromyalgia reflect an energy crisis in your body. Although it can have numerous causes, the energy crisis will then trigger a host of downstream effects, including hypothalamic dysfunction (“blowing a fuse”) which causes multiple other problems including, muscle pain, insomnia, hormonal deficiencies, infections, poor liver detoxification, decreased heart function, and more. Although going after these many triggers and problems is very important, it is also critical to also go to the heart of the problem and treat your body’s “energy furnaces”. Because of this, we will begin our discussion of treatments with those that directly increase energy production.

Testosterone Cypionate

Please Be Advised

Regarding your Testosterone Cypionate suspended in oil for injection;

Storage at low temperatures may result in the separation or “crystallization” of the testosterone within the solution.  Injecting testosterone which has been separated may result in pain and swelling at the site of injection which may persist until the testosterone is completely absorbed from the site.  If you reside in a state with seasonal low temperatures and we shipped your testosterone through mail; please be aware that separation may have occurred, although it may not be visible to you.

The American Journal of Medicine

Volume 127, Issue 6, Pages 547–553, June 2014

Objective

Obesity (as defined by body mass index) has not been associated consistently with higher mortality in older adults. However, total body mass includes fat and muscle, which have different metabolic effects. This study was designed to test the hypothesis that greater muscle mass in older adults is associated with lower all-cause mortality.

By Nelson Vergel
www.TestosteroneWisdom.com

There is so much confusing and contradictory information out there about healthy eating. I will try to summarize what I have learned as a bodybuilder who wants to stay healthy as I age. The choices of foods that we can now can have a significant effect not only on our body shape and quality of life, but also mortality and on how well we age.

ABSTRACT

Introduction: Testosterone deficiency (TD) imposes a substantial public health burden in the U.S. We modeled the costs associated with TD-related sequelae including cardiovascular disease (CVD), diabetes mellitus (DM), and osteoporosis-related fractures (ORFs).

Aim: To quantify the incremental cost burden imposed by TD's cardiometabolic sequelae.

Method: Incidence, prevalence, and mortality of these conditions were collected for men ages 45–74 from six national databases and large cross-sectional studies. Relative risk (RR) rates were determined for these sequelae in patients with T < 300 ng/dL. The prevalence of TD was determined for this cohort of men.

Monday June 30, 2014 (foodconsumer.org) -- A new trial by doctors in Hospital Santa Maria Nuova-IRCCS in Reggio Emilia, Italy suggests that testosterone can be used as a therapeutic agent to treat hormone-responsive breast cancer, particularly in those whose previous hormone therapies have no longer had any effect against the disease.

The study shows that 58.5% patients with metastatic breast cancer whose diseases were initially responsive to hormone therapies, but had become resistant and the diseases were progressing, were responsive to the treatment with testosterone propionate.

Defy Low T during Men’s Health Month

Defy Low T during Men’s Health Month

Author: by Nelson Vergel

Contact: Dr Justin Saya MD: info@defymedical.com

June is Men’s Health Month, and leading up to Father’s Day we celebrate Men’s Health Week (which is June 9 – 15 this year). This is a special awareness period first recognized by Congress in 1994, supported by the Center for Disease Control (CDC) and celebrated around the world. The goal is to educate men and their families and friends about preventable health problems and to encourage them to be more actively involved in their own health care.

One of the most under diagnosed and treated health issues in men is testosterone (T) deficiency. Testosterone deficiency can negatively impact mortality and quality of life in men. To facilitate its diagnosis Defy Medical, a leading integrative health clinic, is launching DefyLowT.com to remove barriers for men who would like to test their testosterone (T) with a dramatically discounted price of $29. The test is performed by blood analysis at a licensed laboratory with locations across the US. Men do not need a prescription and this offer is available in most US cities.

Testosterone replacement therapies come in many forms, according to Nelson Vergel, author of "Testosterone: A Man's Guide." The hormone can be injected into muscle, absorbed through the skin via a cream/gel, or released slowly through a small pellet that's inserted into the body. A doctor does regular blood tests to determine the correct dosage. 

No magic pill 

You've likely read that there's no magic pill for perfect health. While direct-to-consumer marketing may make it seem otherwise, testosterone is no exception, Vergel says. 

For many years there had been a misconception within the general medical community that the male hormone Testosterone caused Prostate Cancer. This misconception was based on flawed studies which were never repeated for some reason. This subsequently resulted in treatment protocols which included chemical castration to eliminate testosterone in men diagnosed with prostate cancer. Unfortunately chemical castration accomplishes nothing except a significant decrease the patient’s quality of life. In addition, when testosterone levels are suppressed too low it will lead to reduced sexual function, decrease in muscle, osteoporosis, depression, anxiety, gynecomastia, and fatigue. All this is brought upon a prostate cancer patient based on a misconception.

Fortunately with the increase in awareness of the benefits of TRT, more research is being conducted on testosterone and its effects. Also, valid studies which have been long ignored due to lack of interest are now being reviewed in support of TRT. Many of us have long known that prostate cancer is unrelated to T levels, now the studies are confirming it.

Responses of different doses of testosterone injections on body composition, strength, etc.

Authors: Bhasin S, et al. , Source: Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1172-81.

Abstract

Testosterone increases muscle mass and strength and regulates other physiological processes, but we do not know whether testosterone effects are dose dependent and whether dose requirements for maintaining various androgen-dependent processes are similar.

To determine the effects of graded doses of testosterone on body composition, muscle size, strength, power, sexual and cognitive functions, prostate-specific antigen (PSA), plasma lipids, hemoglobin, and insulin-like growth factor I (IGF-I) levels, 61 eugonadal men, 18-35 yr, were randomized to one of five groups to receive monthly injections of a long-acting gonadotropin-releasing hormone (GnRH) agonist, to suppress endogenous testosterone secretion, and weekly injections of 25, 50, 125, 300, or 600 mg of testosterone enanthate for 20 wk.

Recent polls have shown that there is almost no training in medical schools for treating overweight and obesity, and that doctors have, in general, a prejudice against such patients. This is ironic when we consider that 1/3 of our patients are obese. As the obesity rate continues to climb, it is important that physicians become more educated in nutrition and the benefit of exercise. Using BMI and outdated dietary recommendations obviously is not working. Get the help you need from an experienced specialist.

TORONTO, May 28, 2014 /CNW/ - Trimel Pharmaceuticals Corporation (TSX: TRL) announced today that the United States Food and Drug Administration (FDA) has approved Natesto™ (testosterone), formerly CompleoTRT™, the first and only testosterone nasal gel for replacement therapy in adult males for conditions associated with a deficiency or absence of endogenous testosterone. Natesto™ is self-administered via a nasal applicator thereby minimizing the risk of secondary exposure to testosterone of women or children.

"In my practice I regularly encounter men demonstrating symptoms of hypogonadism and physicians will increasingly see this as the North American population ages," said Dr. Jeffrey Rosen, the medical director and founder of Clinical Research of South Florida (CRSA). "For these patients seeking to restore their testosterone levels, Natesto™ will offer an alternative delivery system that is safer and more convenient than the other options currently available on the market."

By Kristina Fiore, Staff Writer, MedPage Today Reviewed by Zalman S. Agus, MD; Emeritus Professor, Perelman School of Medicine at the University of Pennsylvania and Dorothy Caputo, MA, BSN, RN, Nurse Planner

A new analysis countered recent studies linking the use of testosterone therapy with increased risks of myocardial infarction (MI) and stroke.

Among roughly 20,000 patients treated with testosterone over a 6-year period, the rate of new MIs was 30 per 100,000 and the rate of new strokes was 10 per 100,000, according to Robert Tan, MD, of OPAL Medical Clinic in Houston.

Those rates were significantly lower compared with rates in the Kaiser Permanente and Northern Manhattan Registry databases (P lees then 0.0001 for both MI and stroke), he reported at the American Association of Clinical Endocrinologists meeting in Las Vegas.

Oxytocin affects social distance between adult males and females, and may be responsible at least in part for romantic attraction and subsequent monogamous pair bonding. An oxytocin nasal spray caused men in a monogamous relationship, but not single men, to increase the distance between themselves and an attractive woman during a first encounter by 10 to 15 centimeters. The researchers suggested that oxytocin may help promote fidelity within monogamous relationships.

Oxytocin Modulates Social Dstance Between Males and Females

Defy Medical offers test kits which analyze things such as your nutritional deficiencies, amino-acid levels, and toxin exposure. More advanced health tests are also available which identify hormone imbalances, cardiovascular disease risk, and gastrointestinal flora. As more patients take an active role in managing their health, and clinicians focus on prevention, these diagnostic tests provide a more complete picture of health and help identify problems before chronic conditions and diseases develop. A color graphic report describes each test result, allowing the development of a personalized approach to optimal health. Each test includes a clinician lab review to determine a nutritional protocol which will address any deficiencies and target your resulting symptoms.

When a person hears the word testosterone, they usually think of a man, a very muscular man full of aggressive energy! Being that testosterone is titled the male hormone and is essentially what makes a man masculine (and becomes an excuse for men to act the way they do!), it might scare most women who learn that testosterone and even human growth hormone are essential to their health and well-being.

As women age, they experience a rapid decline in hormones such as estradiol, progestin, growth hormone, testosterone and DHEA. Although women produce a much lower amount of testosterone than men, this decline is noticed throughout the whole body. Research has shown that testosterone is responsible for a women’s sexual desire and responsiveness, mood, sense of well-being and mental acuity. The Women’s Health Institute at the University of New Jersey suggests that androgens (testosterone) play a significant role in affecting pre-menopausal and post-menopausal symptoms and quality of life!

By Stephen Adams, Medical Correspondent

More aggressive men with higher testosterone levels are less likely to die of heart disease, a study has indicated.

Medics who followed 930 men diagnosed with coronary heart disease found that those with low testosterone were almost twice as likely to die over a seven year period, than those with normal levels of the hormone.

The study, led by Prof Kevin Channer of Royal Hallamshire Hospital in Sheffield, adds weight to recent research overturning the widely-held belief that testosterone increases heart disease risk. During the monitoring period one in five of those with low testosterone levels died, compared with one in eight (12 per cent) of those with normal levels.

Resveratrol, a substance found in the skin of red grapes and in other fruits, has attracted quite a bit of attention in recent years for its potential disease-prevention and anti-aging capabilities

Another Piece of the Healthy Living Puzzle?

Resveratrol, a substance found in the skin of red grapes and in other fruits, has attracted quite a bit of attention in recent years for its potential disease-prevention and anti-aging capabilities. Resveratrol is a type of natural phenol produced naturally by several plants when under attack by pathogens such as bacteria or fungi. Resveratrol acts as a strong antioxidant protecting important cellular structures from oxidative stress and damage and also seems to activate several beneficial genetic pathways that may play a role in increasing longevity.

By John Crisler, DO

In my paper “My Current Best Thoughts on How to Administer TRT for Men”, published in A4M’s 2004/5 Anti-Aging Clinical Protocols, I introduced a new protocol where small doses of Human Chorionic Gonadotrophin (HCG) are regularly added to traditional TRT (either weekly IM testosterone cypionate or daily cream/gel). The reasons and benefits of this protocol are as follows, along with a new improvement I wish to share:

Any physician who administers TRT will, within the first few months of doing so, field complaints from their patients because they are now experiencing troubling testicular atrophy. Irrespective of the numerous and abundant benefits of TRT, men never enjoy seeing their genitals shrinking! Testicular atrophy occurs because the depressed LH level, secondary to the HPTA suppression TRT induces, no longer supports them. It is well known that HCG—a Luteinizing Hormone (LH) analog—will effectively, and dramatically, restore the testicles to previous form and function. It accomplishes this due to shared moiety between the alpha subunits of both hormones.

While Omega-3 Essential fatty acids are necessary for human body functioning, their effects on the working memory of healthy young adults have not been studied until now.

In the first study of its kind, researchers at the University of Pittsburgh have determined that healthy young adults age 18-25 can improve their working memory even further by increasing their omega-3 fatty acid intake. Their findings have been published online in PLOS One. "Before seeing this data, I would have said it was impossible to move young healthy individuals above their cognitive best," said Bita Moghaddam, project investigator and professor of neuroscience. "We found that members of this population can enhance their working memory performance even further, despite already being at the top of their cognitive game."

BOSTON — After daily treatment with a testosterone spray, postmenopausal women have improved cognitive performance in verbal learning and memory, according to results of a pilot study presented here.

Sonia Louise Davison, MD, PhD, a post-doctoral research fellow at Monash University in Melbourne, Australia, said lower testosterone levels in women may contribute to the sex-difference in dementia prevalence, but whether testosterone can improve cognitive performance in women is unknown.

Dimitrakakis C, Jones RA, Liu A, Bondy CA.

Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

OBJECTIVE: There is now convincing evidence that usual hormone therapy for ovarian failure increases the risk for breast cancer. We have previously shown that ovarian androgens normally protect mammary epithelial cells from excessive estrogenic stimulation, and therefore we hypothesized that the addition of testosterone to usual hormone therapy might protect women from breast cancer.DESIGN: This was a retrospective, observational study that followed 508 postmenopausal women receiving testosterone in addition to usual hormone therapy in South Australia.

Long-term testosterone supplementation augments overnight growth hormone secretion

Even though this study used a low dose of testosterone (100 mg every two weeks of testosterone enanthate injections) in older men with low T, it showed that T supplementation can increase night time growth hormone output.

Unprecedented action taken to combat "false information" that has "harmed public health, distorted medical science, and violated the trust between medical journals and the consumer." Failure to retract amounts to "medical literature malpractice."

In an unprecedented action, twenty-five international medical societies have petitioned the Journal of the American Medical Association to retract the article that precipitated recent concerns regarding cardiovascular risks with testosterone therapy, citing "gross data mismanagement" rendering the study "no longer credible."  Twenty-two societies have added their names since the original petition was submitted to JAMA two weeks ago. The article by Rebecca Vigen and colleagues from the University of Colorado, published in the November 13, 2013 issue of JAMA, is entitled "Association of Testosterone Therapy With Mortality, Myocardial Infarction, and Stroke in Men With Low Testosterone Levels."  The results were widely reported as new evidence that testosterone therapy is associated with cardiovascular risks, resulting in a Food and Drug Administration safety bulletin issued January 31, 2014.

"Gross data mismanagement" led to unreliable results that contradicted 30+ years of medical literature, producing a media frenzy that misled consumers and compromised public health

Three professional medical societies and a highly distinguished international group of over 130 scientists and concerned physicians have petitioned the Journal of the American Medical Association to retract the article that precipitated recent concerns regarding cardiovascular risks with testosterone therapy. In a letter addressed to the editor-in-chief of JAMA, Dr. Howard Bauchner, the group cites "gross data mismanagement," rendering the article "no longer credible." The article by Rebecca Vigen and colleagues was published in the November 13, 2013 issue of JAMA, entitled "Association of Testosterone Therapy With Mortality, Myocardial Infarction, and Stroke in Men With Low Testosterone Levels."

Nelson Vergel asks for change in testosterone guidelines after another negative study

A new study published last week and a previous one from the Veterans Administration Hospital System (see below post) show what happens when older men are given testosterone replacement without managing potential blood level increases of factors that can affect their health.

Testosterone replacement can increase red blood cell (and hematocrit which is the total red cell volume) and estradiol production, two important factors for men's health when present in normal levels (red blood cells carry oxygen and estradiol maintains healthy bones, cognitive function and sex drive). However, due to genetic, age or other factors some men can have excessive production of both. High hematocrit and estradiol are more common in older men on testosterone since testosterone related aromatization and erythrocytosis are worse in that population. In excess, both variables have been linked to cardiovascular risks in older men. Not a single one of studies reporting higher cardiovascular risks in men on testosterone have managed either important factor.

Tri-Amino is an injectable amino acid combination which contains three nitric oxide producing agents; L-Arginine, L-Citrulline, and L-Ornithine.  Together these ingredients potentiate blood flow by increasing nitric oxide.  Congestive heart failure, heart disease, peripheral vascular disease, migraines and other diseases may be improved by supplementation with L-arginine to increase Nitric Oxide.  

Arginine is a chemical precursor to nitric oxide (a blood vessel-widening agent called a vasodilator). Early evidence suggests that arginine may help treat medical conditions that improve with increased vasodilation. These conditions include chest pain, atherosclerosis (clogged arteries), heart disease or failure, erectile dysfunction, intermittent claudication/peripheral vascular disease, and vascular headaches.  L-arginine is converted in the body into a chemical called nitric oxide. Nitric oxide causes blood vessels to open wider for improved blood flow. L-arginine also stimulates the release of growth hormone, insulin, and other substances in the body.

SAN FRANCISCO -- Men with chronic pain and opioid-induced androgen deficiency may find some pain relief with testosterone replacement therapy, a small trial suggested.

Although 14 weeks of testosterone did not affect the men's perception of their pain, which was the primary endpoint, the treatment significantly improved objective responses to painful stimuli in a laboratory setting, according to Shehzad Basaria, MD, of Brigham and Women's Hospital in Boston.

At the Endocrine Society meeting here, where Basaria presented the results, he said that the lack of clinical benefit accompanied by changes in objective responses is consistent with prior studies.